The name Humulene comes from the plant where it was first extracted from, Humulus Lupulus, also known as hops. Humulene can be up to 40% of the hops essential oil. Also, its oxidation products in the brewing process give many beers their pleasant hoppy aroma. 


Preventive and therapeutic anti-inflammatory properties of the sesquiterpene α-humulene in experimental airways allergic inflammation:

Rogerio, A. P., Andrade, E. L., Leite, D. F., Figueiredo, C. P., & Calixto, J. B. (2009)


  • Anti-inflammatory effects of compounds alpha-humulene and -trans-caryophyllene isolated from the essential oil of Cordia Verbenaceae.

Fernandes, E. S., Passos, G. F., Medeiros, R., da Cunha, F. M., Ferreira, J., Campos, M. M., Pianowski, L. F., & Calixto, J. B. (2007)


Antitumor activity of balsam fir oil: production of reactive oxygen species induced by alpha-humulene as a possible action mechanism:

Legault, J., Dahl, W., Debiton, E., Pichette, A., & Madelmont, J. C. (2003)

  • Cytotoxic activity of alpha-humulene and trans-caryophyllene from Salvia officinalis in animal and human tumor cells

El Hadri, A., del Río, M. A., Sanz, J., Coloma, A. G., Idaomar, M., Ozonas, B. R., González, J. B., & Reus, M. I. (2010)


Angiogenesis action

  • Wound Healing Effect of Essential Oil Extracted from Eugenia dysenterica DC (Myrtaceae) Leaves.

Sandra Márcia Mazutti da Silva, Claudio Rodrigues Rezende Costa, Guilherme Martins Gelfuso, Eliete Neves Silva Guerra, Yanna Karla de Medeiros Nóbrega, Sueli Maria Gomes, Aline Pic-Taylor, Yris Maria Fonseca-Bazzo, Damaris Silveira, and Pérola de Oliveira Magalhães, (2019)

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