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Alpha-Pinene – Research Profile

Hinted in its name, α-Pinene is commonly found in coniferous trees, notably the pine; It has a very spicy, woody pine aroma. 

a-Pinene is the most widely encountered terpene in nature and has a wide range of medicinal properties. Several studies revealed it as a strong bronchodilator, anti-inflammatory, antibacterial, sedative, and anxiolytic.

Found in – Pine

Anti-inflammatory

Anti-inflammatory and Chondroprotective Activity of (+)-α-Pinene: Structural and Enantiomeric Selectivity.

Rufino, A. T., Ribeiro, M., Judas, F., Salgueiro, L., Lopes, M.C., Cavaleiro, C., & Mendes, A. F. (2014)

https://pubs.acs.org/doi/pdf/10.1021/np400828x

  • Alpha-Pinene Exhibits Anti-Inflammatory Activity Through the Suppression of MAPKs and the NF-κB Pathway in Mouse Peritoneal Macrophages.

Kim DS, Lee HJ, Jeon YD, Han YH, Kee JY, Kim HJ, Shin HJ, Kang J, Lee BS, Kim SH, Kim SJ, Park SH, Choi BM, Park SJ, Um JY, Hong SH. (2015)

https://pubmed.ncbi.nlm.nih.gov/26119957/

 

Sedative

α-Pinene, a significant constituent of pine tree oils, enhances non-rapid eye movement sleep in mice through GABAA-benzodiazepine receptors.

http://molpharm.aspetjournals.org/content/molpharm/early/2016/08/29/mol.116.105080.full.pdf%20

  • Effects of plant-derived odors on sleep-wakefulness and circadian rhythmicity in rats.

Yamaoka, S., Tomita, T., Imaizumi, Y., Watanabe, K., & Hatanaka, A. (2005)

Antinociceptive

Antinociceptive activity of alpha-pinene and fenchone

  • Him, A., Ozbek, H., Turel, I., & Oner, A. C. (2008)

Gastroprotective effect of alpha-pinene and its correlation with antiulcerogenic activity of essential oils obtained from Hyptis species.

https://www.researchgate.net/publication/266416515_Antinociceptive_activity_of_alpha-pinene_and_fenchon

Pinheiro, M. A., Magalhães, R. M., Torres, D. M., Cavalcante, R. C., Xavier Mota, F. S., Oliveira Coelho, E. M. A., Moreira, H. P., Lima, G. C., da Costa Araújo, P. C., Leal Cardoso, J. H. L., de Souza, A. N. C., & Diniz, L. R. L. (2015

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329611/

 

AcH Inhibitor

Inhibitory effect of Turkish Rosmarinus officinalis L. on acetylcholinesterase and butyrylcholinesterase enzymes.

Orhan, I., Aslan, S., Kartal, M., Şener, B., & Hüsnü Can Başer, K. (2008)

https://www.sciencedirect.com/science/article/abs/pii/S0308814607011685?via%3Dihub

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