Characterized by its spicy and peppery odor. This sesquiterpene is most commonly found in cloves, black pepper, basil, oregano, and cannabis. There are three isomers (α-, β-, and γ-caryophyllene) in nature; however, β-Caryophyllene is the most frequently encountered and most abundant of the isomers. Also, as an outstanding feature, β-Caryophyllene is suggested to bind with CB2 receptors and activate the endocannabinoid system. β-Caryophyllene does not produce a psychoactive effect.



Medicinal qualities:
  • Anti-anxiety

β-Caryophyllene, a CB2 receptor agonist, produces multiple behavioral changes relevant to anxiety and depression in mice.

Bahi, A., Al Mansouri, S., Al Memari, E., Al Ameri, M., Nurulain, S. M., & Ojha, S. (2014)


The anxiolytic-like effect of essential oil derived from Spiranthera odoratissima A. St. Hil. Leaves and its major component, β-caryophyllene, in male mice.

Galdino, P. M., Nascimento, M. V., Florentino, I. F., Lino, R. C., Fajemiroye, J. O., Chaibub, B. A., de Paula, J. R., de Lima, T. C., & Costa, E. A. (2012)


β-Caryophyllene, a CB2 receptor agonist, produces multiple behavioral changes relevant to anxiety and depression in mice.

Bahi A1, Al Mansouri S, Al Memari E, Al Ameri M, Nurulain SM, Ojha S.(2014)


  • Anti-inflammatory

Investigation of the anti-inflammatory and analgesic activities of β-Caryophyllene:

Bakır, B., Him, A., Özbek, H., Düz, E., & Tütüncü, M. (2008)

β-Caryophyllene, the major constituent of copaiba oil, reduces systemic inflammation and oxidative stress in arthritic rats.


Ames-Sibin, A. P., Barizão, C. L., Castro-Ghizoni, C. V., Silva, F. M. S., Sá-Nakanishi, A. B., Bracht, L., Bersani-Amado, C. A., & Marçal-Natali, M. R. (2018)


Anti-inflammatory effects of compounds alpha-humulene and (-)-trans-caryophyllene isolated from the essential oil of Cordia Verbenaceae.

Fernandes, E. S., Passos, G. F., Medeiros, R., da Cunha, F. M., Ferreira, J., Campos, M. M., Pianowski, L. F., & Calixto, J. B. (2007)


Amelioration of dextran sulfate sodium-induced colitis in mice by oral administration of beta-caryophyllene, a sesquiterpene.

Cho, J. Y., Chang, H. J., Lee, S. K., Kim, H. J., Hwang, J. K., & Chun, H. S. (2007)


Anti-Inflammatory, Antioxidant, Antibiotic, and Cytotoxic Activities of Tanacetum vulgare L. Essential Oil and Its Constituents

Héloïse Coté, Marie-Anne Boucher, André Pichette, and Jean Legault(2017)


  • Relieves Pain

Involvement of peripheral cannabinoid and opioid receptors in β-caryophyllene-induced antinociception:

Katsuyama S, Mizoguchi H, Kuwahata H, Komatsu T, Nagaoka K, Nakamura H, Bagetta G, Sakurada T, Sakurada S.(2013)

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