myAir science

Linalool – Research Profile

Linalool occurs in over 200 species of plants, commonly in lavender, rose, and citrus. This terpene usually constitutes 5% or less of cannabis essential oil and has pleasant floral notes. Nevertheless, Linalool exhibits strong biological activity. Research studies showed that Linalool is one of the most powerful sedating terpene upon inhalation in mice.

Medicinal qualities:

Anti-anxiety

Effects of inhaled Linalool in anxiety, social interaction, and aggressive behavior in mice:

Linck, V. M., da Silva, A. L., Figueiró, M., Caramão, E. B., Moreno, P. R. H., & Elisabetsky, E. (2010)

https://www.sciencedirect.com/science/article/abs/pii/S0944711309002578

Linalool Odor-Induced Anxiolytic Effects in Mice.

Harada, H., Kashiwadani, H., Kanmura, Y., & Kuwaki, T. (2018)

https://pubmed.ncbi.nlm.nih.gov/30405369/

Reduces opioids dependency

Effect of Linalool on morphine tolerance and dependence in mice.

Hosseinzadeh, H., Imenshahidi, M., Hosseini, M., & Razavi, B. M. (2012)

https://pubmed.ncbi.nlm.nih.gov/22318903/

Analgesic

(-)-Linalool produces antinociception in two experimental models of pain.

Peana, A. T., D’Aquila, P. S., Chessa, M. L., Moretti, M. D., Serra, G., & Pippia, P. (2003)

https://pubmed.ncbi.nlm.nih.gov/12535857/

Antidepressant

Antidepressant activity of Litsea glaucescens essential oil: identification of β-pinene and Linalool as active principles.

Guzmán-Gutiérrez, S. L., Gómez-Cansino, R., García-Zebadúa, J. C., Jiménez-Pérez, N. C., & Reyes-Chilpa, R. (2012)

https://pubmed.ncbi.nlm.nih.gov/22867633/

Sedative

Inhaled linalool-induced sedation in mice.

De Moura Linck, V., da Silva, A. L., Figueiró, M., Piato, Â. L., Herrmann, A. P., Dupont Birck, F., Caramão, E. B., Nunes, D. S., Moreno, P. R. H., & Elisabetsky, E. (2009)

https://www.sciencedirect.com/science/article/abs/pii/S0944711308001529?via%3Dihub

Anti-inflammatory

Anti-inflammatory activity of linalool and linalyl acetate constituents of essential oils:

Peana, A. T., D’Aquila, P. S., Panin, F., Serra, G., Pippia, P., & Moretti, M. D. (2002)

https://pubmed.ncbi.nlm.nih.gov/12587692/

Anticonvulsant

Anticonvulsant properties of Linalool in glutamate-related seizure models:

Elisabetsky, E., Brum, L. F., & Souza, D. O. (1999)

https://pubmed.ncbi.nlm.nih.gov/10374249/

 

 

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